East Region Formulary
NHS Scotland

Uterine fibroids

CKS NICE Fibroids

Treatment of Uterine fibroids – initial management

Prescribing Notes:

  • Refer to national and local gynaecology resources for more information on diagnosis, management, referral criteria and non-pharmacological treatment options for uterine fibroids. Drug treatment options include non-steroidal anti-inflammatory drugs (NSAIDs), tranexamic acid, hormonal contraception, or intrauterine delivery systems. For more information see formulary recommendations for menorrhagia, contraception, or menopausal symptoms.

 

History Notes

21/02/2023

New Pathway agreed ERWG Jan 2023

Treatment of Moderate to Severe Uterine Fibroids – specialist management

Restricted to use in patients who have failed or are unsuitable for conventional therapies (first line treatments), such as tranexamic acid, hormonal contraceptives, and intrauterine delivery systems.

Relugolix + Estradiol + Norethisterone acetate
Ryeqo 40mg/1mg/0.5mg tablets

In adult women of reproductive age, 1 tablet once daily, dose to be taken at around the same time each day, starting within 5 days of the onset of menstrual bleeding, consider discontinuing treatment when patient enters menopause.

Restricted to use in patients when conventional first-line treatments (such as tranexamic acid, hormonal contraceptives and intrauterine devices) have failed or are considered unsuitable.

Linzagolix
Linzagolix 100mg tablets

For dosing refer to BNF or product literature.

Linzagolix 200mg tablets

For dosing refer to BNF or product literature.

Prescribing Notes:

  • The position of specialist treatment in this condition pathway is not intended to guide on place in therapy. The place in therapy is directed by a specialist gynaecologist experienced in the management of the condition, use is in line with relevant local or national guidance.

 

History Notes

10/09/2025

Updated prescribing information, ERWG Aug 2025

21/02/2023

New Pathway agreed ERWG Jan 2023